A server computer and a multitude of client computers form a network computing system that is scalable and adapted to continue to evaluate the performance characteristics of a number of genes generated using a software application running on the client computers. The invention also relates to the use of same in therapeutics. The matched MPRs may then be used by a medical professional to diagnose a patient condition. A first via arranged in a substrate of the semiconductor die is connected between the first bond pad and an interconnecting layer. Each cache line is to store corresponding data and a foreground tag that includes a respective virtual address associated with the corresponding data, and that includes the associated stale indicator. The invention also provides footwear which includes a footbed as described herein.