In an endsocopic treatment instrument, a distal end of a manipulating wire extending from the distal end of a sheath is provided with a large-diameter portion that is large enough to be incapable of passing through an engagement through-hole in the plate portion of an actuating member. Also disclosed are substrates at least partially coated with a coating deposited from such a composition and multi-component composite coatings, wherein at least one coating later is deposited from such a coating composition. Using the present invention, an edge router can provide exact QoS guarantee and QoS routing control for the application flows. This prevents the engine from generating noises excessively.