The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. Each aeration tube is connected at each tube end thereof to one of the connection ports, and each connection port is connected to a tube end such that the connected aeration tubes and hollow connectors form a substantially rigid structure. The apparatus may further include a blade, such as a knife-like blade, disposed inside the mixing andor cavitation chamber opposite the orifice component.