Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided:wherein: R1, R2, R3, R4 and R5 are as defined herein which are useful as inhibitors of plasminogen activator inhibitor-1 for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis. The printable absorbent surface includes a permanent image of colors having half tones. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. The host cell may be a plant cell and the plant may be comprised in a transgenic plant.