A \u201cfield of view\u201d consists of all possible directions along which scalar valued functions satisfy selected thresholds. Endothelial cells along with pericyte, vascular smooth muscle, andor mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. The diaphragm is exposed to ambient pressure on a first side thereof and exposed to a positive pressure within the facepiece on a second side thereof. The system also includes a multi-zone thermal adjustment unit that contains a plurality of thermal coupler elements, which are configured to adjust the temperature of the pre-defined zones. , inputoutput buffers that may be placed along the periphery of the integrated circuit, the savings can be extraordinary. , to monitor or discover the target device.