A high pressure apparatus and related methods for processing supercritical fluids are disclosed. Techniques disclosed herein can enable a faster and more efficient process by which a processor can seek from one point of time in a data stream to another point of time in that data stream to bring a played-back application to a desired point in time. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer’s disease. Thus, the electric field is distributed in the intrinsic region of the Ge\u2014Si photodiode where there is low dislocation density. An in-process semiconductor device is also described. The output from the low gain amplifier may be used as a voltage output node that provides a voltage that is an amplification of the voltage produced by the floating signal source.