The present invention relates to modulators of ATP-Binding Cassette transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator, compositions thereof, and methods therewith. The processing apparatus can have a low-profile nozzle system capable of navigating through spaces in order to process target regions with relatively small clearances. Once speech data representative of the current program channel has been generated, an audible announcement of the program channel may be made to the user, thereby enabling visually impaired individuals to ascertain the currently selected program channel.