A golf ball comprises a molded core, one or more ionomer mantles, and a thermoset polyurethane cover. Each of the flaps includes a first flap portion and a second flap portion, and before final assembly, the first flap portion is connected to a first side plate and the second flap portion is connected to the first flap portion, bent with respect to the first flap portion and affixed to one of the second side plates. The charge holding element further includes a plurality of electrodes. The locking device is oriented into operative and inoperative positions by the engagement and disengagement of locking elements. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer’s disease, Alzheimer’s disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson’s disease, Huntington’s disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.