Optoelectronic devices of the present invention include several embodiments of an electronically active optical waveguide made of a strip loaded waveguide with a lateral, self-aligned diode fabricated in a layer of silicon. Also disclosed is the 3-D structure of the hRI\u2022RNase 1 complex and methods for designing the RNase 1 variants. The reflective surfaces include at least a first reflective surface, a second reflective surface, and a third reflective surface. In this case executable code may replace both instances of the markup language element with a single instance having the first attribute and the second attribute.