\u03b2-Lactamase inhibitor compounds are disclosed, including compounds that have activity against class A, class C or class D \u03b2-lactamases. The handle includes a hub that fits at least in part within the first zone and can be rapidly engaged within the second zone so to attach the appendage to the handle while allowing rotational movement of the hub within the second zone. That is, a cache design is disclosed that enables cache data to be speculatively accessed before a determination is made as to whether a memory address required to satisfy a received memory access request is truly present in the cache.