The invention provides a compound of Formula I,Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. For example, methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic acid salt. The last-obtained partially corrected signal is output as the reduced-crest factor signal. All of these various, non-heat active humidifier modules are components or attachments to a CPAP device, and all optionally employ various procedures and devices for dealing with excess condensation.