The invention provides a novel splice-variant of the ClC-4 protein, termed ClC-4A. The memory cells may have a first electrode, and a trench-shaped programmable material structure over the first electrode. The device can include additional weights that can be attached to the device for various exercises. The timing assembly includes a housing and a plurality of timing gears disposed within the housing. The optical source signal may be communicated into the CMOS chip and the first optical signals may be communicated from the CMOS chip via optical couplers, which may comprise grating couplers.