The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition, and a second dimension adapted for determining molecular weight or particle size. When a touch position is to be measured, substitute RkRo to the equation of RLRoRkRV2 so as to obtain a touch position.