Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. The pre-load pad 70 restricts displacement in relation to the widthwise direction, by one side face portion of a holder 61 fixed to a gear housing 22. The wireless device includes any wireless apparatus having wireless communications capabilities.