An integrated circuit is formed on a substrate. Also disclosed are methods of using such compounds and compositions to inhibit aspartyl protease, and to treat a variety of disease and indications including to cardiovascular disease and cognitive and neurodegenerative disease. The present invention further provides a cured composition of matter that is non-swellable in water after curing, comprising a water soluble copolymer comprising acrylamide and glycidyl methacrylate; and a water soluble secondary aromatic amine.