A weld head angle adjustment system includes a weld head, a base unit, and an angle adjustment mechanism. The compounds of the invention have affinity for the nociceptin receptor. At least one gill tube may be stacked atop the sand tube and stitched together to form a wall of desired height. An adjustment unit adjusts a density of the attention pixel based on the distance measured with the detecting unit and a spot diameter of the light on a surface of the photoconductor. A PCB comprising waveguides and an optical component sub-mount for integrating with the PCB is also presented. According to the invention the dose setting mechanism allows adjustment in both directions, such that a given set dose can be reduced or cancelled by reversing the input motion, typically by rotating a setting member backwardly, this in contrast to the known devices which either requires an additional release mechanism or which cannot be reversed at all.