The present invention relates to pharmaceutical compositions containing certain flavonoid glycoside-type compounds that have been shown in the present invention to be therapeutically useful, including useful as analgesics and anti-inflammatories for the treatment and management of pain and inflammatory conditions. The thickness of the outer shell is about 5 to 20% of the diameter of the inner particle core of said catalyst particle, preferably comprising at least 3 atomic layers. The load may be achieved by magnetically biasing the impeller. Each of the first passgate and the second passgate are coupled to receive respective pairs of control signals to control opening and closing of the passgates, wherein the scan enable signal controls which of the respective pairs of control signals are pulsed. Also included are methods of making and using these co-stimulatory polypeptides.