Specific binding members, featuring certain residues of the third CDR of the antibody NH576 are provided, together with their use in methods of treatment and diagnosis. The high cyclization temperature and long cyclization period of conventional polyamic acid resin compositions can be lowered and shorten by the additives of the invention. The flow regulator is adjustable while positioned within the wellbore to change the flow rate. Each tier has a convex surface annularly formed on an inner periphery thereof for scattering light beams emitted from different angles. The formulation has a viscosity in the range of from 3 to 10 cP and a surface tension of from 35 to 50 mNm, and is prepared using a UF resin composition exhibiting a viscosity of from 175 to 250 cP. The control units use the sequence of these messages to keep all components within the router in sync.