The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. The communication device may comprise a microprocessor for processing data received from the electrical equipment in the remote location. A greater amount of boosting can be provided for a lower data state which represents a lower threshold voltage and hence is more vulnerable to program disturb. The light projected from the second light source is perceptibly dominant in a higher-frequency portion of the visible spectrum. Less than one liter of dialysate is required to circulate through the wearable CRRT device.