A method of reducing formation of non-natural disulfide bonds in a mature IFN-\u03b1 by adding one or more amino acid residues to its N-terminus cystein. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE andor on platelets of the individual obtained at a different time. When the usable bit rate on the network is poor and below that necessary for conducting a live conversation, voice media is transmitted and received by the communication device at the available usable bit rate on the network. The encryption device and method and decryption device and method process encrypted text that is based upon a stream structure with an unlimited key length and may be compressed by 50%. The management operation is then performed or ignored in accordance with results of the human-based authentication.