A manufactured granular substrate composition suitable for use as a carrier for active chemical agents. The first and second plates have male and female parts having interlocking elements cooperable with one another enabling movement of the plates and the adjacent vertebrae to one another to progressively compress the bone graft between the adjacent vertebrae and prevent movement of the first and second plates and adjacent vertebrae away from one another. The cylindrical jacket is disposed opposite the metal roll to form a calender nip so that the sheet of paper is continuously passed through the calender nip. Terminals for handling the calls are also connected to the network.