This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of determined sequence. The open metal structure, independent of the ceramic matrix composite, has a total metal volume percent in the range of about 10% to about 90%, with no dimension of any open shape being greater than about \xbe inch. The final solid product can be made into any shapes or forms that the matrix can be made into without the addition of the ash. Thus, a coating film having a boundary with a compositional gradient in the thickness direction or a coating film having a two-layer structure composed of a layer of ingredient A and a layer of ingredient B is deposited by sputtering through one-direction conveyance. The peripheral wall has an electromagnet-loading opening through which electromagnet pedestal members and the electromagnets are inserted into the casing and secured therein. The devices are controlled by a set of auxiliary ones of the distributed operative voltages spanning an auxiliary range within the effective range, so that a difference between the voltage applied to each pair of terminals thereof is not higher than the safe voltage.