An electrolytic capacitor cell for use in implantable medical devices and associated method for manufacture are provided. An institution system may receive and analyze transaction data associated with the purchase. The results of the evaluation are the fancy yarn parameters such as base yarn mass, base yarn diameter, slub distance, mass increase of a slub, slub diameter increase, slub diameter, slub length andor slub total mass. At least one of the first set of programs has a counterpart in the second set of programs. A plurality of second non-dielectric pillars and first vias are formed in a first low-k dielectric layer underlying the topmost low-k layer in the scribe line region, wherein the second non-dielectric pillars electrically connect the first non-dielectric pillars by the first vias, respectively. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective inhibitors of TNF signaling pathways.