In a networked system in which high speed busses interconnect sources and destinations of data, systems for and methods of flow control and extended burst transfers are described. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound andor electro-stimulation to a patient. In one embodiment, a self-refresh rate of a DRAM is adjusted based on the SPID of that device. In the situation where the client station is a wireless handset or other wireless communication device, the method is particularly advantageous, as the method can reduce the number of air interface communications and can thus help to conserve valuable air interface resources.