What is disclosed is a system and method for method for fitness evaluation to be used with a directly calculated or iterative optimization method for automatic document assembly. The methods include using pleconaril as a prodrug for conversion to anti-picornaviral compounds in vivo. An encoder provides encoded data and includes a first PLL. An open fuse indication device is in communication with conducting portions of the fuse, and an alarm terminal output extends from the switch assembly housing and is in communication with the open fuse indication device. As a result the method can be used for a variety of therapeutic applications, as well as to study cell lineages and organogenesis, plus the capacity that residual stem cells have for regeneration. The present invention also relates to a corresponding transmission method for transmitting OFDM-signals.