The present invention provides an amino-imidazolone compound of formula IAlso provided are compositions and methods for the use thereof to inhibit \u03b2-secretase and treat \u03b2-amyloid deposits and neurofibrillary tangles. The rear section has a through-hole extending from a first face of the rear section through a second face of the rear section opposite to the first face. An edge of the sheet is attached to an edge of the panel.