A method of inhibiting chytochrome P450 enzymes selected from the group consisting of CYP1A2, CYP2A6 and CYP3A4 comprises the step of administering an effective inhibition amount of AHT-323A botanical extract to a patient. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect. The fasteners preferably comprise dual-width fasteners which exhibit enhanced pull-out resistance values. Another embodiment includes a central circuit that controls the position of electricity to an electric blanket responsively to temperature rate of change.