Suturing rings and methods of use thereof facilitating initial implantation of new and replacement of dysfunctional tissue or mechanical heart valve mechanisms supported by the suturing ring are disclosed. A resin layer for serving as a dielectric layer of the capacitor portion is formed on a surface of the wiring layer using an electrophoretic process. The apparatus also comprises a circuit breaker or switching component, wherein the circuit breaker or switching component is in operable communication with the over-current protective component. Sand that is scooped up together with the waste is allowed to drop through the gaps in the grating-like portion. The apparatus can include one or more arrays of N over-damped, bi-stable circuits unidirectionally-coupled from element to element. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin.