A handheld electronic device includes a reduced QWERTY keyboard and is enabled with disambiguation software. The buffer layer is formed on the substrate. A stage converts input voltage to an amplified output voltage, a stage converting an input voltage in to an output current and a final stage where the outputs of the two previous sections are supplied as inputs. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.