Embodiments of the present invention provide mechanisms that overcome limitations of existing indexes by creating two-dimensional spatial indexes to quickly locate data containers that match two or more predicates. The cartridge assembly includes a component carrying body that has a plurality of separate component reservoirs and a component flow directing housing at a forward end of the reservoirs. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder. At least one of the chambers formed between substrates 12 and 14 and electrochromic device 22 may be filled with an insulating gas such as argon. It is useful as a therapeutic agent for autoimmune diseases such as chronic rheumatoid arthritis, systemic lupus erythematodes and multiple sclerosis as well as for various immunodeficiency syndromes wherein the immune system is not functioning properly. , and brings some of the comparators to the operating state and holds the remaining comparators in the resting state.