For efficient detection or observation of a skin disease, especially skin cancer, methods for examining the skin of a subject and an associated device are specified. Also disclosed are methods of synthesizing such oxadiazole compounds. In response to a miss in the cache, an invalid cache line is identified from information in the cache directory by the invalid cache line selection unit. Receive circuitry is located on a second side of galvanic isolation and configured to receive the optical signal with an optical sensor. A published virtual paper is scaled to a physical paper, taking into account the virtual paper’s size, geometry bounds for an image from the virtual paper being printed, balanced geometry bounds calculated from the geometry bounds, the physical paper’s size and a printable area of the physical paper, so that the image being printed fits within a printable area of the physical paper. The fuel rail includes an elongated member that is corrugated such that the fuel rail acts as a pressure damper.