An electrosurgical biopsy device includes a stylet with a shaft, a head and an ablation element, a cannula with a distal end opening and an ablation element adjacent the opening, and optionally a base. An arm arrangement is rotatably attached to the clamping mechanism. The disc drive implemented method also involves detecting at the current burst whether data to be written to a following wedge will encroach upon data written in adjacent tracks and allowing the data to be written in the following wedge when the encroachment is not too severe. The nanoparticle fibers are specifically designed to have a desirable 3D network depth and porosity, as well as nanoparticle average diameter, standard deviation, and nanoparticle separation, as well as nanoparticle crystal phase composition, stoichiometry, and crystallinity. 3% of wet tissue weight for a time ranging from about 30 seconds to about 10 minutes. The method involves subjecting an aqueous, polyol product mixture to ion-exclusion chromatography to separate and reduce impurities from an eluant fraction containing a desired product, and distilling the eluant fraction to yield the desired product.