Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. A memory device as described herein includes a first electrode layer, a second electrode layer, and a thermal isolation structure including a layer of thermal isolation material between the first and second electrode layers. The initiation layer may comprise or consist of cobalt, tantalum, nickel, titanium or TaAlC. If the key is found, the storage location is used to identify a memory address associated with the result table.