The present invention provides the compounds of formula I-Atheir pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer. The outer preform has legs 38, 40 that extend longitudinally and laterally from a fold 42. Each recess has a first side, having a first profile, adjacent to the channel region and a second side, having a second profile, adjacent to a trench isolation region. New incoming data from the sub-systems is continually compared with the stored data to identify abnormalities. Another, empty shopping cart is positioned in an unloading zone. Graphite powder having a maximum particle diameter of less than 100 \u03bcm and an existing fraction of rhombohedral structure in the crystalline structure of less than 20% is used as an active material for the negative electrode of the non-aqueous secondary battery.