A screening method of identifying a compound for treating hepatitis. A Rayleigh backscatter signal is detected for each interrogating pulse as a function of time between the launching of the pulse and the detection of the backscatter signal. A derating factor of the circuit design is determined as a function of the estimated toggle rates of the plurality of circuit elements. The engine has wordsized suitable code capable of adding, subtracting, multiplying, squaring, or inverting finite field elements, as long as the elements are representable in no more than the given number of words. In some embodiments, the data exchange facilitated by the third party platform may be customized based on user-specified appliance center settings.