The invention relates to the asynchronous communication of data in complex integrated systems, be it inside integrated circuit chips or between integrated circuit chips, for example in a compact stack of chips. The shift stage controller generates the information of the shift pattern including the shift pattern and transmits it to the touch screen, and generates stage shift information allotted to the input information received from the touch screen and transmits it to the controller of the electronic auto-transmission of the vehicle. Each actuator of the array of actuators is movably coupled to one micromirror of the array of movable micromirrors and can move the micromirror both vertically and rotationally. These estimated network metrics are employed to make an application layer decision of whether the client connection is a high latency, low-bandwidth connection. In one embodiment, the system includes: a check code generator that transforms the interface of the dynamically linkable component into an interface identifier representing the interface and couples the interface identifier to the dynamically linkable component and a interface verifier that employs the interface identifier to determine a compatibility of the dynamically linkable component. The nanoparticles that are produced by the disclosed methods range in diameter size from about 100 ran to about 400 nm, with a preferred diameter size of from approximately 100 nm to approximately 300 nm, thereby rendering them non-immunogenic.