Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods. The instant invention may also include an adjustable base, a plurality of prongs on the outer pole for assisting with guiding the flag into the outer pole slot, a cap attached to the top of the inner pole in a manner that receives the prongs into the cap and electronic controls. Mechanisms for replenishment of the device and methods for application of the device in remote sites of the body are disclosed. Optionally, these ingredients can be combined with at least one of Aframomum, Rosmarinic acid, and Tinospora.