A method for treating diabetic complications by administration of a beta-blocker is disclosed. An engine-stop controlling means includes limiting means for limiting the differential state of a differential portion by a switching brake and a switching clutch when the operational state of a first electric motor is limited. Moreover, the steering-wheel lock may further include at least one blocking device for selectively blocking a steering spindle, the at least one blocking device being selectively actuatable by the key. The piston retaining sleeve may include a maintenance aperture for installing or repairing a pinion and a second aperture for viewing the rotation of the pinion. Additional trench isolation structures may be interposed between portions of the substrate on which bond pads are formed and other portions of the substrate to prevent capacitive coupling between the bond pad structures and the substrate, thereby enhancing the high frequency operations of the image sensor.