A method of scoring binding affinity of a proposed ligand molecule for a receptor molecule using a computer and computer data bases, which accounts for the increase in energy required where docking disrupts water molecules that are localized at ligand hydration sites. The first router receives, from a second router associated with the second network node, a map response that includes a particular device location that corresponds to the particular device identifier for the second network node. The motor is configured to drive the mechanical transmission assembly and the mechanical transmission assembly is configured to drive the drive mechanism, wherein the return mechanism exerts an axial pressure against the endless screw in such a way as to press the endless screw against the support element. The frame defines two fixing holes, corresponding to the fixing posts. Consequently, C5 olefins can be added to C4 olefins in an oligomerization feed stream to produce more gasoline and less distillate. The sweetener composition can be formulated as cubes, granules for use in sachets or packets, and tablets.