A signal controller device with an input, at least two outputs, a coupling unit for detecting a frequency of a signal arriving on the input and generating a detection signal. In one particular exemplary embodiment, the techniques may be realized as a system for multiple pass geolocation. Finally, the hash code is generated using the input bits. Then the memory address space allocated to the calling process that stores data obtained from an untrusted source is identified. Whether a ratio of the targeted object to the first video image is smaller than or equal to a first threshold is determined when the target object enters into the designated region. The protein kinase C inhibitors may be selected from sphingosine, sphinganine, phytosphingosine, curcumin, tetrahydrocurcumin, curcuminoids or apigenin.