Machine, method for use and method for making, and corresponding products produced thereby, as well as data structures, computer-readable media tangibly embodying program instructions, manufactures, and necessary intermediates of the foregoing, each pertaining to digital aspects of a computerized aggregation system. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating chronic pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. However, the DRAM is typically not included in ASIC or FPGA implementations of encoders and decoders due to complex refresh requirements of DRAM that are required to maintain data stored in DRAM and may interfere with user access to the memory space during refresh cycles. Optionally, an underlying dielectric layer, such as a shallow trench isolation, may be recessed under the notch, thereby reducing gap fill issues. In one aspect the body 505\u2032 is a bone dowel comprising an off-center plug from the diaphysis of a long bone. The coating may contain a titanium aluminum nitride layer applied by a physical vapor deposition.