In a liquid crystal display device in which picture elements are arranged in a matrix form, a fixed time before a display data voltage is supplied to the picture element by a data line and a scan line, a pre-write voltage at a gradation value having a high speed of response to a change in gradation is supplied to the picture element regardless of the gradation value of a picture after response. The aqueous dispersion comprises from 10 to 60% of the globular elastomer particles of 0. Backlights of a keyboard are caused to be illuminated to colors based on respective dominant colors. It is more preferable that the uneven surface and the stopper layer are simultaneously formed with a layer used for forming pixels in a step for forming such a layer thus preventing the increase of manufacturing steps. The envelope weld member is in electrical communication so as to be at operating potential of one of the first and second electrodes when the x-ray tube is energized. The invention is also directed to methods of determining the effect of a candidate agent on any subject’s risk of developing bone or joint disease.