A tubeless tire is embedded with elliptical cylinder-shaped elastic members. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. If the exiting road has a smaller number of traffic lanes, an intersection guidance is provided. The floating gates are formed on the tunneling oxide layer, and each of floating gates is located between each source and the drain. The process of the present invention is adaptable to sulfating a wide range of alcohols including the hydroxyl unit which terminates a polyalkoxylate moiety which are prevalent in the area of surfactants, inter alia, alkyl ethoxy sulfates.