A composition includes an alkali-soluble resin having Mw of 1500 to 10000, a quinonediazide ester of, for example, the following formula, and a phenolic compound containing an acid-decomposable group. If all of the foregoing steps are positive, the cancer is treated by applying imiquimod transdermally to rotating sites, preferably by mixing ALDARA\u2122 5% cream with an equal amount of H base cream \u2122, administering a BCG vaccination, and orally administering VALTREX\u2122 twice daily. The roll change tube is then pivoted to move the roll change tube away from the core shaft to position the tissue web rolls for delivery to a downstream process, and simultaneously a core change tube is moved into coaxial alignment with the core shaft so that new cores can be pushed from the core change tube onto the core shaft. As the device changes form, shape or state, it gradually contacts the trough or flow diverting more or less concentrate in a controlled manner. Accordingly, the compounds of formula may be employed for the prevention and the treatment of impaired glucose tolerance, Type 2 diabetes and obesity.