A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon . The side-entry leak protector provides for improved fluid sealing against fluid that might enter a sonde sub proximate the side-mounted sensor component. By mapping two adjacent physical cells as a single logical cell, the flash memory device can be programmed and erased on a single bit or variable bit length basis with conventional technologies. The guidewire may include an outer coil disposed around at least a portion of the elongate core wire. The adhesive helps to position the system to the patient, and placement of the surgical implements inside the envelope helps to ensure sterility of the implements.