An apparatus and method for routing data packet connection pathways. Each of the K pictures is divided into an m>1 row\xd7n>1 column array of non-overlapping coding units of equal sizes. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Another aspect of the present invention comprises a location-based Uniform Resource Locator that includes a protocol semantic portion and a location-based resolver address portion that identifies one or more resources on a network based on the geographical location of the resources.