A method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. Articles formed from the compositions are also disclosed. In some embodiments, an aggregation of various external data sources as well as internal data can be used to better predict when a user should be reminded of the time for their event, determine and advise whether they may be late regardless, andor enable the user to arrange a delegate or replacement or to reschedule or cancel the event. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.