A method, apparatus, and computer program for cognitive radio communications are provided. A carrier control circuit comprises a reference voltage generator, a comparator, and a controller. The command request contains a command and a locale in which the text of the result is desired. If the user selects a second task to be executed, the controller can determine which of the registered applications is to be used to execute the second task. The application provides compositions comprising hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.