The present invention is a method and apparatus for contaminant detection of body parts, such as hands, and or their coverings, such as clean room suits or gloves, and small objects. In particular, the methods and devices relate to contacting a target tissue with a pharmaceutical in a re-circulating, oxygenated perfusate solution to provide for effective delivery of the pharmaceutical to the target tissue. The engagement member selectively removably cooperates with a recess formed in the parking and lock system.