A system for creating a project is disclosed. Also provided by the invention are methods of screening for agents that modulate the activity or expression of a RAMP and methods of treating mammals to modulate liver function andor muscle metabolism. The method continues with the processing module generating, based on retrieved metadata, a third retrieval request for retrieving at least a portion of a data object associated with the data object name, where the third retrieval request is formatted in accordance with the read request format of the DSN. Thus, the storage location for a content unit on the OAS system may be the zone on the OAS system to which the object identifier for the content unit maps. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced eIF-5A are identified and the nucleotide sequences of each, alone and in combination are used to modify senescence in transgenic plants. Various uses for thse molecules are described.